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Submit ReviewDantrolene, sodium salt
说明： Ca2+ release inhibitor
化学名： 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt
纯度： ≥98% (HPLC)
生物活性 for Dantrolene, sodium salt
Inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
技术数据 for Dantrolene, sodium salt
| 分子量 | 336.23 |
| 公式 | C14H9N4NaO5 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 14663-23-1 |
| PubChem ID | 6604100 |
| InChI Key | KSRLIXGNPXAZHD-HAZZGOGXSA-M |
| Smiles | O=C([N-]3)N(CC3=O)/N=C/C1=CC=C(C2=CC=C([N+]([O-])=O)C=C2)O1.[Na+] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Dantrolene, sodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 3.36 | 10 |
制备储备液 for Dantrolene, sodium salt
以下数据基于产品分子量 336.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.74 mL | 148.71 mL | 297.42 mL |
| 0.5 mM | 5.95 mL | 29.74 mL | 59.48 mL |
| 1 mM | 2.97 mL | 14.87 mL | 29.74 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.95 mL |
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产品说明书 for Dantrolene, sodium salt
参考文献 for Dantrolene, sodium salt
参考文献是支持产品生物活性的出版物。
Hotchkiss and Karl (1994) Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia. Proc.Natl.Acad.Sci.U.S.A. 91 3039 PMID: 8159702
O'Mara et al (1995) Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the rat dentate gyrus. Neuroscience 68 621 PMID: 8577362
Zhao et al (2001) Dantrolene inhibition of ryanodine receptor Ca2+ release channels. J.Biol.Chem. 276 13810 PMID: 11278295
Merck Index 12 2879
If you know of a relevant reference for Dantrolene, sodium salt, please let us know.
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关键词: Dantrolene, sodium salt, Dantrolene, sodium salt supplier, Ca2+, release, inhibitors, inhibits, Calcium, Signaling, Signalling, Agents, General, ryanodine, receptors, ion, channels, Ryanodine, Receptors, 0507, Tocris Bioscience
9 篇 Dantrolene, sodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Dantrolene, sodium salt 的部分引用包括：
Florea et al (2017) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma. Oncotarget 8 22876 PMID: 28206967
Agarwal et al (2017) Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93 587 PMID: 28132831
Battefeld et al (2019) High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep 26 182 PMID: 30605675
Wang et al (2015) Role of Na+/Ca2+ exchanger in Ca2+ homeostasis in rat suprachiasmatic nucleus neurons. J Neurophysiol 113 2114 PMID: 25568156
Efthymiou et al (2015) Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. Int J Mol Sci 4 230 PMID: 25637190
Lin et al (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. FEMS Immunol Med Microbiol 16 5555 PMID: 25768340
Patel et al (2009) Mobilization of calcium from intracellular stores facilitates somatodendritic DA release. J Neurosci 29 6568 PMID: 19458227
Wieland et al (2006) Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. J Pharmacol Exp Ther 47 296 PMID: 16831218
Drdla and Sandkühler (2008) Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo. Mol Pain 4 18 PMID: 18507818
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Dantrolene modulates synaptic function.
By
Anonymous on 08/17/2019
分析类型： In Vitro
种属： Rat
细胞系/组织： Hippocampus
Dantrolene was used to test impact of Ca2+ efflux from internal stores on neurotransmitter vesicle release in living neurons. Dantrolene, being added to intracellular solution, suppressed release of synaptic vesicles. Figure: change of a neuron electrical capacitance in response to series of electrical stimuli. Increase of electrical capacitance reflects increased number of vesicles fusing with cell membrane.
