DBM 1285 dihydrochloride

Cat. No. 5095 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： p38 MAPK inhibitor; anti-inflammatory

化学名： N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-2-pyrimidinamine dihydrochloride

纯度： ≥98% (HPLC)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DBM 1285 dihydrochloride

DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Attenuates zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Orally active.

技术数据 for DBM 1285 dihydrochloride

分子量	468.42
公式	C₂₁H_22FN₅S.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1782532-29-9
PubChem ID	90489008
InChI Key	ANQWETXPBPZVOF-UHFFFAOYSA-N
Smiles	FC(C=C4)=CC=C4C1=C(C2=CC=NC(NC5CC5)=N2)SC(C3CCNCC3)=N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DBM 1285 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	46.84	100

制备储备液 for DBM 1285 dihydrochloride

以下数据基于产品分子量 468.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.67 mL	21.35 mL
5 mM	0.43 mL	2.13 mL	4.27 mL
10 mM	0.21 mL	1.07 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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产品说明书 for DBM 1285 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DBM 1285 dihydrochloride

参考文献是支持产品生物活性的出版物。

Kang et al (2010) DBM1285 suppresses tumor necrosis factor α production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. J.Pharmacol.Exp.Ther. 334 657 PMID: 20427474

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关键词: DBM 1285 dihydrochloride, DBM 1285 dihydrochloride supplier, DBM1285, dihydrochloride, P38, MAPK, inhibits, inhibitors, TNF-alpha, TNF-a, TNF-α, mitogen, activated, protein, kinase, 917811-28-0, p38, 5095, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for DBM 1285 dihydrochloride

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.