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dBRD9-A

Cat. No. 6943 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent BRD9 Degrader (PROTAC®)
化学名： 2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)octyl)acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for dBRD9-A

dBRD9-A is a potent BRD9 Degrader (PROTAC®). Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model. BRD9 antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # NBP3-14730.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license

许可信息

Sold under license from Dana-Farber Cancer Institute

技术数据 for dBRD9-A

分子量 779.88
公式 C42H49N7O8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2170679-42-0
PubChem ID 139370810
InChI Key ZDINQSNMYRVAGP-UHFFFAOYSA-N
Smiles COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCCCCCCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for dBRD9-A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 77.99 100
ethanol 7.8 10

制备储备液 for dBRD9-A

以下数据基于产品分子量 779.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.41 mL 12.82 mL
5 mM 0.26 mL 1.28 mL 2.56 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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参考文献 for dBRD9-A

参考文献是支持产品生物活性的出版物。

Brien et al (2018) Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife 7 e41305 PMID: 30431433

If you know of a relevant reference for dBRD9-A, please let us know.

按标靶查看相关产品

关键词: dBRD9-A, dBRD9-A supplier, potent, selective, bromodomains, BRD9, active, degraders, degrades, PROTAC, PROTACs, sarcoma, targeted, protein, degradation, tpd, Bromodomains, Bromodomain, (BRD), Degraders, 6943, Tocris Bioscience

1 篇 dBRD9-A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 dBRD9-A 的部分引用包括：

Nazar et al (2022) SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma. Nat Genet 54 861-873 PMID: 35681054

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia