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dBRD9

Cat. No. 6606 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective BRD9 Degrader (PROTAC®)
化学名： 2-[[[4-(1,2-Dihydro-2-methyl-1-oxo-2,7-naphthyridin-4-yl)-2-6-dimethoxyphenyl]methyl]methylamino]-N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]acetamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for dBRD9

dBRD9 is a potent and selective Degrader (PROTAC®) of BRD9 (IC50 = 56.6 nM in MOLM-13 cells). dBRD9 is composed of the BRD9 inhibitor BI 7273 conjugated to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). Does not degrade BRD4 or BRD7 at concentrations up to 5 μM. Displays antiproliferative effects in human AML cell lines. BRD9 antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # NBP3-14730.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

许可信息

Sold under license from Dana-Farber Cancer Institute.

技术数据 for dBRD9

分子量 856.75
公式 C40H45N7O10.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2341840-98-8
PubChem ID 135397681
InChI Key AIOCFZJGGGEWDK-UHFFFAOYSA-N
Smiles COC1=CC(C2=CN(C(C3=CN=CC=C23)=O)C)=CC(OC)=C1CN(CC(NCCOCCOCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O)C.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for dBRD9

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 17.14 20
DMSO 42.84 50

制备储备液 for dBRD9

以下数据基于产品分子量 856.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 2.33 mL 11.67 mL 23.34 mL
2.5 mM 0.47 mL 2.33 mL 4.67 mL
5 mM 0.23 mL 1.17 mL 2.33 mL
25 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

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Reconstitution Calculator

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产品说明书 for dBRD9

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for dBRD9

参考文献是支持产品生物活性的出版物。

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID: 28418626

If you know of a relevant reference for dBRD9, please let us know.

按标靶查看相关产品

关键词: dBRD9, dBRD9 supplier, 2170679-45-3, BRD9, degrading, active, degraders, PROTAC, PROTACs, Proteolysis, Targeting, Chimeras, targeted, protein, degradation, tpd, BAF, complex, factor, bromodomains, cereblon, e3, ligase, potent, selective, Bromodomains, Bromodomain, (BRD), Degraders, 6606, Tocris Bioscience

3 篇 dBRD9 的引用文献

引用文献是使用了 Tocris 产品的出版物。 dBRD9 的部分引用包括：

Nasun et al (2022) BRD9 regulates interferon-stimulated genes during macrophage activation via cooperation with BET protein BRD4. Proc Natl Acad Sci U S A 119 PMID: 34983841

Ma et al (2023) Engineered PROTAC-CID systems for mammalian inducible gene regulation J Am Chem Soc 145 1593 PMID: 3662658

Loo et al (2020) A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function Immunity 53 143 PMID: 32640256

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia