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DC 271

Cat. No. 6873 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Fluorescent retinoic acid analog; solvochromatic probe
化学名： 4-[2-[1,2,3,4-Tetrahydro-4,4-dimethyl-1-(1-methylethyl)-6-quinolinyl]ethynyl]benzoic acid
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DC 271

DC 271 is a fluorescent retinoic acid analog (retinoid all-trans-retinoic acid; ATRA) (Kd = 42 nM at cellular retinoid binding protein II (CRABPII)). Solvochromatic probe: fluorescent λex, λem, and quantum yield affected by solvent type. DC 271 can be used in retinoids assays. Activates same genes as endogenous retinoic acid in human keratinocyte cells (HaCaT) when incubated for 72 h at 1 μM. Also elicits cellular responses consistent with those of retinoic acid. Excitation λ = 351, 350, 382 and 378 nm in DMSO, EtOH, DCM and Toluene, respectively; emission λ = 442, 461, 572 and 447 nm in DMSO, EtOH, DCM and Toluene, respectively. Quantum yield = 19.3, 1.14, 71.45, 80.21 % in DMSO, EtOH, DCM and Toluene, respectively.

技术数据 for DC 271

分子量 347.46
公式 C23H25NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 198696-03-6
PubChem ID 22971725
InChI Key OCMSZODRCJAGHL-UHFFFAOYSA-N
Smiles CC(N1CCC(C)(C2=CC(C#CC3=CC=C(C(O)=O)C=C3)=CC=C12)C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DC 271

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.37 50
ethanol 3.47 10

制备储备液 for DC 271

以下数据基于产品分子量 347.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.76 mL 28.78 mL 57.56 mL
2.5 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
25 mM 0.12 mL 0.58 mL 1.15 mL

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参考文献 for DC 271

参考文献是支持产品生物活性的出版物。

Chisholm et al (2019) Fluorescent retinoic acid analogues as probes for biochemical and intracellular characterization of retinoid signaling pathways. ACS.Chem.Biol. 14 369 PMID: 30707838

Tomlinson et al (2021) Structure-functional relationship of cellular retinoic acid-binding proteins I and II interacting with natural and synthetic ligands. Acta Crystallogr. D Struct. Biol. 77 164 PMID: 33559606

Tomlinson et al (2018) Novel Fluorescence Competition Assay for Retinoic Acid Binding Proteins ACS.Med.Chem.Lett. 9 1297

If you know of a relevant reference for DC 271, please let us know.

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关键词: DC 271, DC 271 supplier, DC271, Fluorescent, retinoic, acid, analogs, analogues, cellular, retinoid, binding, protein, II, CRABPII, solvochromatic, Tretinoin, ATRA, Retinoic, Acid, Receptors, Retinoid, X, Receptor, Acid-related, Orphan, ESCs, and, iPSC, Organoids, Probes, Fatty, Binding, Proteins, 6873, Tocris Bioscience

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该领域的文献

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Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.