DCPIB

Name: DCPIB
Brand: Tocris Bioscience
SKU: 1540
Rating: 4 (1 reviews)

Cat. No. 1540 17 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Blocker of VRAC/I_{Cl, swell}

别名： SN-401

化学名： 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid

纯度： ≥98% (HPLC)

说明书

引用文献 (17)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DCPIB

DCPIB is a volume-regulated anion channel (VRAC) blocker (IC₅₀ ~ 2 μM in rat pancreatic β-cells). Also blocks I_Cl,swell in various cardiovascular tissues (IC₅₀ = 4.1 μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect K_ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Also activates TREK1 and TRAAK K⁺ channels and inhibits TRESK, TASK1 and TASK3 K⁺ channels at 10 μM, in vitro. Also inhibits VRAC-mediated 2'3'-cyclic-GMP-AMP (cGAMP) transport.

技术数据 for DCPIB

分子量	427.37
公式	C₂₂H₂₈Cl₂O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	82749-70-0
PubChem ID	10071166
InChI Key	KHKGTPJPBOQECW-UHFFFAOYSA-N
Smiles	CCCCC1(CC2=C(C1=O)C(Cl)=C(Cl)C(OCCCC(O)=O)=C2)C1CCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DCPIB

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	ethanol	42.74	100

制备储备液 for DCPIB

以下数据基于产品分子量 427.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.7 mL	23.4 mL
5 mM	0.47 mL	2.34 mL	4.68 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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产品说明书 for DCPIB

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DCPIB

参考文献是支持产品生物活性的出版物。

Bourke et al (1981) Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative. J.Neurosurg. 55 364 PMID: 6267227

Decher et al (2001) DCPIB is a novel selective blocker of I_Cl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br.J.Pharmacol. 134 1467 PMID: 11724753

Best et al (2004) Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. Eur.J.Pharmacol. 489 13 PMID: 15063150

Lv et al (2019) DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K_2P channels. ACS.Chem.Neurosci. 10 2786 PMID: 30935201

Lahey et al (2020) LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP. Mol.Cell. 80 1 PMID: 33171122

If you know of a relevant reference for DCPIB, please let us know.

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