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Decynium 22

Cat. No. 4722 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4722 has been discontinued.

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说明： PMAT inhibitor
化学名： 1-Ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]quinolinium iodide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Decynium 22

Decynium 22 is an inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM).

技术数据 for Decynium 22

分子量 454.35
公式 C23H23IN2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 977-96-8
PubChem ID 101932
InChI Key GMYRVMSXMHEDTL-UHFFFAOYSA-M
Smiles CC[N+]2=C(/C=C3/N(CC)C(C=CC=C4)=C4C=C3)C=CC1=CC=CC=C12.[I-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Decynium 22

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Decynium 22

参考文献是支持产品生物活性的出版物。

Engel and Wang (2005) Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol.Pharmacol. 68 1397 PMID: 16099839

Xia et al (2009) Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity. Am.J.Physiol.Renal Physiol. 296 F1307 PMID: 19357181

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关键词: Decynium 22, Decynium 22 supplier, Decynium22, PMAT, plasma, membrane, monoamine, transporters, inhibitors, inhibits, Nucleoside, Transporters, 4722, Tocris Bioscience

1 篇 Decynium 22 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Decynium 22 的部分引用包括：

He et al (2017) Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage. Glia 65 1251 PMID: 28543680

Decynium 22 的评论

平均评分: 4 (Based on 1 Review.)

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Also a non-competitive alpha-1 adrenoceptor antagonist.
By Alex Voisey on 10/25/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： Aorta

Excellent for blocking organic cation transport at 1 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.

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