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Deoxynivalenol

Cat. No. 3976 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Mycotoxin; potent protein synthesis inhibitor
别名： DON,Vomitoxin
化学名： 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Deoxynivalenol

Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.

技术数据 for Deoxynivalenol

分子量 296.32
公式 C15H20O6
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 51481-10-8
PubChem ID 40024
InChI Key LINOMUASTDIRTM-QGRHZQQGSA-N
Smiles CC1=C[C@]2([H])[C@]([C@@](C)(C[C@H]4O)[C@]3(CO3)[C@@]([H])4O2)(CO)[C@H](O)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Deoxynivalenol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 8.89 30

制备储备液 for Deoxynivalenol

以下数据基于产品分子量 296.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.3 mM 11.25 mL 56.25 mL 112.49 mL
1.5 mM 2.25 mL 11.25 mL 22.5 mL
3 mM 1.12 mL 5.62 mL 11.25 mL
15 mM 0.22 mL 1.12 mL 2.25 mL

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产品说明书 for Deoxynivalenol

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Deoxynivalenol

参考文献是支持产品生物活性的出版物。

Bae and Pestka (2008) Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicol.Sci. 105 59 PMID: 18502741

Shi et al (2009) Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicol.Sci. 109 247 PMID: 19336499

Krishnaswamy et al (2010) Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression. Free Radic.Biol.Med. 49 50 PMID: 20347963

If you know of a relevant reference for Deoxynivalenol, please let us know.

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关键词: Deoxynivalenol, Deoxynivalenol supplier, DON, vomitoxin, cytotoxic, mycotoxin, protein, synthesis, inhibitors, inhibits, 3a,7a,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, Vomitoxin, Miscellaneous, Compounds, 3976, Tocris Bioscience

1 篇 Deoxynivalenol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Deoxynivalenol 的部分引用包括：

Vivien et al (2020) The mycotoxin deoxynivalenol activates GABAergic neurons in the reward system and inhibits feeding and maternal behaviours. Arch Toxicol 94 3297-3313 PMID: 32472169

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