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Dexrazoxane hydrochloride

Cat. No. 3857 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Topoisomerase II inhibitor
别名： ICRF-187
化学名： 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Dexrazoxane hydrochloride

Dexrazoxane hydrochloride is a topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

技术数据 for Dexrazoxane hydrochloride

分子量 304.73
公式 C11H16N4O4.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1263283-43-7
PubChem ID 6918223
InChI Key BIFMNMPSIYHKDN-FJXQXJEOSA-N
Smiles C[C@@H](CN2CC(NC(C2)=O)=O)N(CC(N1)=O)CC1=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Dexrazoxane hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 30.47 100
DMSO 30.47 100

制备储备液 for Dexrazoxane hydrochloride

以下数据基于产品分子量 304.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.41 mL 32.82 mL
5 mM 0.66 mL 3.28 mL 6.56 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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产品说明书 for Dexrazoxane hydrochloride

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Dexrazoxane hydrochloride

参考文献是支持产品生物活性的出版物。

Lebrecht et al (2007) Dexrazoxane prevents doxorubicin-induced long-term cardiotoxicity and protects myocardial mitochondria from genetic and functional lesions in rats. Br.J.Pharmacol 151 771 PMID: 17519947

Spallarossa et al (2010) Sublethal doses of an anti-erbB2 antibody leads to death by apoptosis in cardiomyocytes sensitized by low prosenescent doses of epirubicin: the protective role of dexraz. J.Pharmacol.Exp.Ther. 332 87 PMID: 19841470

Classen et al (2003) Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc.Natl.Acad.Sci. 100 10629

If you know of a relevant reference for Dexrazoxane hydrochloride, please let us know.

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关键词: Dexrazoxane hydrochloride, Dexrazoxane hydrochloride supplier, topoisomerase, II, inhibitors, inhibits, DNA, isomerases, ICRF187, chemotherapeutics, ICRF-187, DNA,, RNA, and, Protein, Synthesis, Topoisomerase, 3857, Tocris Bioscience

1 篇 Dexrazoxane hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Dexrazoxane hydrochloride 的部分引用包括：

Gardner et al (2011) Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells. Breast Cancer Res 13 R53 PMID: 21595939

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该领域的文献

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