DG 172 dihydrochloride

Name: DG 172 dihydrochloride
Brand: Tocris Bioscience
SKU: 5566

Cat. No. 5566 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5566 has been discontinued.

View all Non-selective PPAR products.

说明： Potent PPARβ/δ inverse agonist; promotes BMC differentiation

化学名： (αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for DG 172 dihydrochloride

DG 172 dihydrochloride is a potent PPARβ/δ inverse agonist (IC₅₀ = 26.9 nM). Inhibits Angptl4 gene expression in mouse myoblasts (IC₅₀ = 9.5 nM) in vitro. Also augments GM-CSF/IL-4-induced differentiation of mature dendritic cells from bone marrow cells in culture. Orally available.

技术数据 for DG 172 dihydrochloride

分子量	455.22
公式	C₂₀H₂₀BrN₃.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1361504-77-9
PubChem ID	57342888
InChI Key	SABUORLIDVBCPI-WTLOABTRSA-N
Smiles	BrC(C=CC=C1)=C1/C(C#N)=C/C2=CC=C(N3CCN(C)CC3)C=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for DG 172 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DG 172 dihydrochloride

参考文献是支持产品生物活性的出版物。

Lieber et al (2015) The inverse agonist DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiation. Mol.Pharmacol. 87 162 PMID: 25398837

Lieber et al (2012) (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J.Med.Chem. 55 2858 PMID: 22369181

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篇 DG 172 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 DG 172 dihydrochloride 的引用文献。