Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDianicline
Discontinued Product
5557 has been discontinued.
说明： Selective α4β2 nAChR partial agonist
化学名： (5aS,8S,10aR)-5a,6,9,10-Tetrahydro-7H,11H-8,10a-methanopyrido[2',3':5,6]pyrano[2,3-d]azepine
纯度： ≥98% (HPLC)
生物活性 for Dianicline
Selective α4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable.
技术数据 for Dianicline
| 分子量 | 289.2 |
| 公式 | C13H16N2O.2HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 292634-27-6 |
| PubChem ID | 121513869 |
| InChI Key | WYIKBRGLNDJDEU-CQSOCPNPSA-N |
| Smiles | [H][C@]12[C@](CN3CC2)(CC3)CC4=NC=CC=C4O1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Dianicline
参考文献 for Dianicline
参考文献是支持产品生物活性的出版物。
Rollema et al (2010) Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br.J.Pharmacol. 160 334 PMID: 20331614
按产品操作查看相关产品
关键词: Dianicline, Dianicline supplier, nicotinic, acetylcholine, receptors, nAChR, partial, agonists, agonism, selective, α, β, alpha4beta2, orally, bioavailable, Nicotinic, (a4b2), Receptors, 5557, Tocris Bioscience
Dianicline 的评论
目前没有该产品的评论。 Be the first to review Dianicline and earn rewards!
Have you used Dianicline?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.