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Submit ReviewDiazepam
说明： Acts at the benzodiazepine modulatory site
别名： Ro 5-2807
化学名： 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one
纯度： ≥98% (HPLC)
生物活性 for Diazepam
Diazepam is a ligand at the GABAA receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.
技术数据 for Diazepam
| 分子量 | 284.74 |
| 公式 | C16H13ClN2O |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 439-14-5 |
| PubChem ID | 3016 |
| InChI Key | AAOVKJBEBIDNHE-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(N(C)C(CN=C2C3=CC=CC=C3)=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Diazepam
参考文献 for Diazepam
参考文献是支持产品生物活性的出版物。
Sieghart et al (1994) Pharmacology of benzodiazepine receptors: an update. J.Psychiat.Neurosci. 19 24
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关键词: Diazepam, Diazepam supplier, Acts, benzodiazepine, modulatory, site, GABAA, Receptors, Ro52807, Ro, 5-2807, 2805, Tocris Bioscience
8 篇 Diazepam 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Diazepam 的部分引用包括：
Brodnik et al (2018) Local GABAA receptor mediated suppression of DA release within the nucleus accumbens. ACS Chem Neurosci 17 1978 PMID: 30253088
Zhu (2018) Structure of a human synaptic GABAA receptor. Nature 559 67 PMID: 29950727
Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. PLoS One 40 766 PMID: 25249058
Ufuk et al (2015) In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383. Pharm Res 32 3937 PMID: 26224396
Pytka et al (2015) Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT?A and 5-HT? Antagonists in Animal Models. PLoS One 10 e0142499 PMID: 26554929
Fairless et al (2013) Membrane potential measurements of isolated neurons using a voltage-sensitive dye. PLoS One 8 e58260 PMID: 23516458
Stuart et al (2013) A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology 38 1625 PMID: 23503126
Huang et al (2010) A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure. J Neurosci 30 16636 PMID: 21148002
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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