DIDS

Name: DIDS
Brand: Tocris Bioscience
SKU: 4523
Rating: 5 (1 reviews)

Cat. No. 4523 10 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Chloride channel blocker; TRPV1 modulator; RAD51 recombinase inhibitor

化学名： 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid disodium salt

纯度： ≥95% (HPLC)

说明书

引用文献 (10)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DIDS

DIDS is a ClC-Ka chloride channel blocker (IC₅₀ = 100 μM). Blocks the maxi chloride channel in apical membranes from human placenta. Displays antagonistic activity at TRPM4 and TRPC4 channels; potentiates agonist-induced TRPV1 currents (IC₅₀ = 4.88 μM in rat DRG neurons). Inhibits RAD51 recombinase activity (K_D = 2 μM).

技术数据 for DIDS

分子量	498.48
公式	C₁₆H₈N₂Na₂O₆S₄
储存	Store at +4°C
纯度	≥95% (HPLC)
CAS Number	67483-13-0
PubChem ID	5702690
InChI Key	GEPAYBXVXXBSKP-SEPHDYHBSA-L
Smiles	[Na+].[Na+].[O-]S(=O)(=O)C1=C(\C=C\C2=C(C=C(C=C2)N=C=S)S([O-])(=O)=O)C=CC(=C1)N=C=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DIDS

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	Potassium bicarbonate (0.1M)	2.49	5

制备储备液 for DIDS

以下数据基于产品分子量 498.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.05 mM	40.12 mL	200.61 mL	401.22 mL
0.25 mM	8.02 mL	40.12 mL	80.24 mL
0.5 mM	4.01 mL	20.06 mL	40.12 mL
2.5 mM	0.8 mL	4.01 mL	8.02 mL

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产品说明书 for DIDS

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DIDS

参考文献是支持产品生物活性的出版物。

Ishida et al (2009) DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 37 3367 PMID: 19336413

Wulff (2008) New light on the "old" chloride channel blocker DIDS. ACS Chem.Biol. 3 399 PMID: 18642798

Zhang et al (2012) Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives. Mol.Pharmacol. 81 689 PMID: 22328719

Riquelme and Parra et al (1999) Regulation of human placental chloride channel by arachidonic acid and other cis unsaturated fatty acids. Am.J.Obstet.Gynecol. 180 469 PMID: 9988821

If you know of a relevant reference for DIDS, please let us know.

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