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DIM-C-pPhOCH3

Cat. No. 6376 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Nur77 agonist
化学名： 1,1-Bis(3'-indolyl)-1-(p-methoxyphenyl)methane
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for DIM-C-pPhOCH3

DIM-C-pPhOCH3 is a Nur77 agonist. Induces apoptosis in cancer cell lines in vitro. Enhances long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse model.

技术数据 for DIM-C-pPhOCH3

分子量 352.43
公式 C24H20N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 33985-68-1
PubChem ID 11371604
InChI Key ZCCMKJAXOIFTHH-UHFFFAOYSA-N
Smiles COC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for DIM-C-pPhOCH3

参考文献是支持产品生物活性的出版物。

Bridi et al (2017) Pharmacological activators of the NR4A nuclear receptors enhance LTP in a CREB/CBP-dependent manner. Neuropsychopharmacology 42 1243 PMID: 27834392

Chintharlapalli et al (2005) Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem. 280 24903 PMID: 15871945

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关键词: DIM-C-pPhOCH3, DIM-C-pPhOCH3 supplier, Nur77, NR4A1, agonists, agonism, NGFI-Balpha, α, apoptosis, memory, long-term, potentiation, LTP, Other, Transcription, Factors, Nerve, Growth, Factor, IB-like, Receptors, 6376, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for DIM-C-pPhOCH3

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.