DIM-C-pPhOH

Cat. No. 6377 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Nur77 antagonist

化学名： 1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane

纯度： ≥98% (HPLC)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DIM-C-pPhOH

DIM-C-pPhOH is a Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines. Mimics effects of Nur77 RNAi silencing.

技术数据 for DIM-C-pPhOH

分子量	338.408
公式	C₂₃H₁₈N₂O
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	151358-47-3
PubChem ID	2940609
InChI Key	QCPDFNWJBQMXLI-UHFFFAOYSA-N
Smiles	OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DIM-C-pPhOH

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	33.84	100
	ethanol	33.84	100

制备储备液 for DIM-C-pPhOH

以下数据基于产品分子量 338.408。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.55 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.3 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.3 mL	0.59 mL

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产品说明书 for DIM-C-pPhOH

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DIM-C-pPhOH

参考文献是支持产品生物活性的出版物。

Chintharlapalli et al (2005) Activation of Nur77 by selected 1,1-Bis(3-indolyl)-1- (p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem 280 24903 PMID: 15871945

Hedrick et al (2016) NR4A1 antagonists inhibit 1-Integrin-dependent breast cancer cell migration. Mol.Cell.Biol 36 1383 PMID: 26929200

Lee et al (2014) The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Mol.Cancer Res. 12 527 PMID: 24515801

If you know of a relevant reference for DIM-C-pPhOH, please let us know.

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关键词: DIM-C-pPhOH, DIM-C-pPhOH supplier, Nur77, antagonists, antagonism, nuclear, receptor, proapoptotic, cancer, cell, migration, inhibitors, inhibits, Nerve, Growth, Factor, IB-like, Receptors, 6377, Tocris Bioscience

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该领域的文献

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MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for DIM-C-pPhOH

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.