Diminazene aceturate

Name: Diminazene aceturate
Brand: Tocris Bioscience
SKU: 6705

Cat. No. 6705 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6705 has been discontinued.

View all Acid-Sensing Ion Channels products.

说明： ASIC blocker; antihyperalgesic

化学名： 4,4'-(1-Triazene-1,3-diyl)bis[benzenecarboximidamide] bis(N-acetylglycinate)

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for Diminazene aceturate

Diminazene aceturate is an ASIC blocker (IC₅₀ values are 202, ~320, ~320 and 864 nM for ASIC1b, ASIC1a, ASIC3 and ASIC2a, respectively). Exhibits no activity in ENaC channels expressed in oocytes. Accelerates desensitization of ASIC currents in hippocampal neurons. Inhibits mesotrypsin (K_i = 3.6±0.3 μM). Displays in vitro and in vivo anti-inflammatory effects in mice. Antihyperalgesic.

技术数据 for Diminazene aceturate

分子量	515.52
公式	C₁₄H₁₅N₇.2C₄H₇NO₃
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	908-54-3
PubChem ID	5284544
InChI Key	OKQSSSVVBOUMNZ-UHFFFAOYSA-N
Smiles	CC(NCC(O)=O)=O.CC(NCC(O)=O)=O.NC(C1=CC=C(C=C1)N/N=N/C2=CC=C(C(N)=N)C=C2)=N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Diminazene aceturate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Diminazene aceturate

参考文献是支持产品生物活性的出版物。

Lee et al (2018) Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. Br.J.Pharmacol. 175 2204 PMID: 29134638

Kayode et al (2017) Small molecule inhibitors of mesotrypsin from a structure-based docking screen. PLoS One 12 e0176694 PMID: 28463992

Chen et al (2010) Diarylamidines: high potency inhibitors of acid-sensing ion channels. Neuropharmacology 58 1045 PMID: 20114056

Krauson et al (2018) Molecular basis of inhibition of acid sensing ion channel 1A by diminazene. PLoS One 13 e0196894 PMID: 29782492

Goru et al (2017) Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes. Br.J.Pharmacol. 174 3118 PMID: 28688122

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