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说明： Selective aryl hydrocarbon receptor modulator (SAhRM)
化学名： 2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
纯度： ≥99% (HPLC)
生物活性 for DiMNF
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Suppresses expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment; exhibits no effect on basal CD55 or CD46 expression.
技术数据 for DiMNF
| 分子量 | 332.35 |
| 公式 | C21H16O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 14756-24-2 |
| PubChem ID | 276138 |
| InChI Key | QDZQDIUUJDAORK-UHFFFAOYSA-N |
| Smiles | O=C2C=C(C4=CC(OC)=C(OC)C=C4)OC1=C3C(C=CC=C3)=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DiMNF
参考文献 for DiMNF
参考文献是支持产品生物活性的出版物。
Labrecque et al (2012) Distinct roles for aryl hydrocarbon receptor nuclear translocator and Ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS ONE 7 e29545 PMID: 22235307
Murray et al (2011) Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol.Pharmacol. 79 508 PMID: 21127131
Narayanan et al (2012) Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J.Pharmacol.Exp.Ther. 342 345 PMID: 22553215
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关键词: DiMNF, DiMNF supplier, DiMNF, aryl, hydrocarbon, receptors, AhRs, modulators, SAhRMs, anti-inflammatories, anti-inflammatory, Aryl, Hydrocarbon, Receptors, 4628, Tocris Bioscience
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