(±)-Anatoxin A fumarate

Name: (±)-Anatoxin A fumarate
Brand: Tocris Bioscience
SKU: 0789

Cat. No. 0789 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0789 has been discontinued.

View all Nicotinic Receptors (Non-selective) products.

说明： nAChR agonist

化学名： (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate

纯度： ≥96% (HPLC)

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for (±)-Anatoxin A fumarate

(±)-Anatoxin A fumarate is a potent nicotinic agonist (K_i values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). (±)-Anatoxin A fumarate stimulates [³H]-dopamine release from rat striatal synaptosomes (EC₅₀ = 136 nM). (±)-Anatoxin A fumarate induces apoptosis in rat thymocytes and Vero cells by generation of reactive oxygen species and caspase activation.

技术数据 for (±)-Anatoxin A fumarate

分子量	281.31
公式	C₁₀H₁₅NO.C₄H₄O₄
储存	Store at +4°C
纯度	≥96% (HPLC)
CAS Number	1219922-30-1
PubChem ID	45073416
InChI Key	ZJSIFVODFDHYJU-WLHGVMLRSA-N
Smiles	O=C(C)C1=CCCC2CCC1N2.O=C(O)/C=C/C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (±)-Anatoxin A fumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (±)-Anatoxin A fumarate

参考文献是支持产品生物活性的出版物。

Gordon et al (1992) Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 263 997 PMID: 1469655

Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 20 2783 PMID: 10751429

Stolerman et al (1992) Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 31 311 PMID: 1630597

Thomas et al (1993) (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 60 2308 PMID: 8492133

Lakshmana Rao et al (2002) Involvement of caspase and reactive oxygen species in cyanobacterial toxin anatoxin-a-induced cytotoxicity and apoptosis in rat thymocytes and Vero cells. Arch.Toxicol. 76 227 PMID: 12029386

Campos et al (2007) In vivo neurochemical characterization of Anatoxin-a evoked dopamine release from striatum. J.Neural Transm. 114 173 PMID: 16897603

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关键词: (±)-Anatoxin A fumarate, (±)-Anatoxin A fumarate supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, nAChR, (±)-AnatoxinA, fumarate, (Non-selective), Apoptosis, Inducers, 0789, Tocris Bioscience

1 篇 (±)-Anatoxin A fumarate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (±)-Anatoxin A fumarate 的部分引用包括：

Gagnon and Pick (2012) Effect of nitrogen on cellular production and release of the neurotoxin anatoxin-a in a nitrogen-fixing cyanobacterium. Front Microbiol 3 211 PMID: 22701451