(±)-Anatoxin A fumarate

Cat. No. 0789 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： nAChR agonist

化学名： (±)-2-Acetyl-9-aza bicyclo[4.2.1]non-2-ene fumarate

纯度： ≥96% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (±)-Anatoxin A fumarate

(±)-Anatoxin A fumarate is a potent nicotinic agonist (K_i values are 1.25 and 1840 nM for α4β2 and α7 nicotinic receptors respectively). (±)-Anatoxin A fumarate stimulates [³H]-dopamine release from rat striatal synaptosomes (EC₅₀ = 136 nM). (±)-Anatoxin A fumarate induces apoptosis in rat thymocytes and Vero cells by generation of reactive oxygen species and caspase activation.

技术数据 for (±)-Anatoxin A fumarate

分子量	281.31
公式	C₁₀H₁₅NO.C₄H₄O₄
储存	Store at +4°C
纯度	≥96% (HPLC)
CAS Number	1219922-30-1
PubChem ID	45073416
InChI Key	ZJSIFVODFDHYJU-WLHGVMLRSA-N
Smiles	O=C(C)C1=CCCC2CCC1N2.O=C(O)/C=C/C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (±)-Anatoxin A fumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	28.13	100

制备储备液 for (±)-Anatoxin A fumarate

以下数据基于产品分子量 281.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.55 mL	17.77 mL	35.55 mL
5 mM	0.71 mL	3.55 mL	7.11 mL
10 mM	0.36 mL	1.78 mL	3.55 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

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产品说明书 for (±)-Anatoxin A fumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (±)-Anatoxin A fumarate

参考文献是支持产品生物活性的出版物。

Gordon et al (1992) Induced release of acetylcholine from guinea pig ileum longitudinal muscle myenteric plexus by anatoxin-A. J.Pharmacol.Exp.Ther. 263 997 PMID: 1469655

Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 20 2783 PMID: 10751429

Stolerman et al (1992) Behavioural effects of anatoxin, a potent nicotinic agonist in rats. Neuropharmacology 31 311 PMID: 1630597

Thomas et al (1993) (+)-Anatoxin is a potent agonist at neuronal nicotinic acetylcholine receptors. J.Neurochem. 60 2308 PMID: 8492133

Lakshmana Rao et al (2002) Involvement of caspase and reactive oxygen species in cyanobacterial toxin anatoxin-a-induced cytotoxicity and apoptosis in rat thymocytes and Vero cells. Arch.Toxicol. 76 227 PMID: 12029386

Campos et al (2007) In vivo neurochemical characterization of Anatoxin-a evoked dopamine release from striatum. J.Neural Transm. 114 173 PMID: 16897603

If you know of a relevant reference for (±)-Anatoxin A fumarate, please let us know.

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关键词: (±)-Anatoxin A fumarate, (±)-Anatoxin A fumarate supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, nAChR, (±)-AnatoxinA, fumarate, (Non-selective), Apoptosis, Inducers, 0789, Tocris Bioscience

1 篇 (±)-Anatoxin A fumarate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (±)-Anatoxin A fumarate 的部分引用包括：

Gagnon and Pick (2012) Effect of nitrogen on cellular production and release of the neurotoxin anatoxin-a in a nitrogen-fixing cyanobacterium. Front Microbiol 3 211 PMID: 22701451

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