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Submit ReviewDL-AP4 is a broad spectrum EAA ligand.
D-isomer, L-isomer and Sodium Salt also available.
分子量 | 183.1 |
公式 | C4H10NO5P |
储存 | Store at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 6323-99-5 |
PubChem ID | 2207 |
InChI Key | DDOQBQRIEWHWBT-UHFFFAOYSA-N |
Smiles | O=C(C(N)CCP(O)(O)=O)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 9.15 | 50 |
以下数据基于产品分子量 183.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.5 mM | 10.92 mL | 54.61 mL | 109.23 mL |
2.5 mM | 2.18 mL | 10.92 mL | 21.85 mL |
5 mM | 1.09 mL | 5.46 mL | 10.92 mL |
25 mM | 0.22 mL | 1.09 mL | 2.18 mL |
参考文献是支持产品生物活性的出版物。
Evans et al (1979) Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog. Br.J.Pharmacol. 67 591 PMID: 316343
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024
If you know of a relevant reference for DL-AP4, please let us know.
关键词: DL-AP4, DL-AP4 supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, 20263-07-4, Non-selective, mGlu, 0101, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 DL-AP4 的部分引用包括:
Ferlauto et al (2018) Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis. Nat Commun 9 992 PMID: 29520006
Chrispell et al (2018) Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish. Invest Ophthalmol Vis Sci 59 5116 PMID: 30372740
Schmidt and Kofuji (2011) Structure and function of bistratified intrinsically photosensitive retinal ganglion cells in the mouse. J Comp Neurol 519 1492 PMID: 21452206
Schmidt and Kofuji (2009) Functional and morphological differences among intrinsically photosensitive retinal ganglion cells. J Neurosci 29 476 PMID: 19144848
Sekaran et al (2005) Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina. Curr Biol 15 1099 PMID: 15964274
Vinberg et al (2015) A new mouse model for stationary night blindness with mutant Slc24a1 explains the pathophysiology of the associated human disease. Hum Mol Genet 24 5915 PMID: 26246500
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.