(±)-Bisoprolol hemifumarate

Name: (±)-Bisoprolol hemifumarate
Brand: Tocris Bioscience
SKU: 0914

Cat. No. 0914 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0914 has been discontinued.

View all Adrenergic β<sub>1</sub> Receptors products.

说明： β₁ antagonist

化学名： (±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate

纯度： ≥98%

说明书

引用文献 (3)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for (±)-Bisoprolol hemifumarate

A selective β₁-adrenergic antagonist. Has a K_d of 2-3 nM at the β₁ receptor and a β₁/β₂ selectivity of approximately 100-fold.

技术数据 for (±)-Bisoprolol hemifumarate

分子量	383.48
公式	C₁₈H₃₁NO₄.½C₄H₄O₄
储存	Store at RT
纯度	≥98%
CAS Number	104344-23-2
PubChem ID	5281064
InChI Key	VMDFASMUILANOL-WXXKFALUSA-N
Smiles	OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (±)-Bisoprolol hemifumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (±)-Bisoprolol hemifumarate

参考文献是支持产品生物活性的出版物。

Heible et al (1995) α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428

Kaumann and Lemoine (1985) Direct labelling of myocardial β₁-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency. Naunyn Schmiedebergs Arch.Pharmacol. 331 27 PMID: 2866449

Klockow et al (1986) Studies on the receptor profile of bisop. Arzneimittelforschung 36 197 PMID: 2870719

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关键词: (±)-Bisoprolol hemifumarate, (±)-Bisoprolol hemifumarate supplier, α1-adrenoceptor, beta1-adrenoceptor, β1-Adrenergic, beta1-Adrenergic, b1-adrenoceptor, b1-adrenergic, antagonists, Receptors, Adrenergic, Beta-1, 0914, Tocris Bioscience

3 篇 (±)-Bisoprolol hemifumarate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (±)-Bisoprolol hemifumarate 的部分引用包括：

Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486 PMID: 21865315

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. PLoS One 355 183 PMID: 26306764

Kam et al (2005) Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ channels in the heart from ovariectomized rats. Br J Pharmacol 144 972 PMID: 15685204