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Submit Review(±)-Epibatidine
说明： High affinity nAChR agonist
化学名： (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane
纯度： ≥98% (HPLC)
生物活性 for (±)-Epibatidine
(±)-Epibatidine is a high affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.
许可信息
Sold under license from the NIH, US Patent 5,314,899
技术数据 for (±)-Epibatidine
| 分子量 | 208.69 |
| 公式 | C11H13ClN2 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 148152-66-3 |
| PubChem ID | 1204 |
| InChI Key | NLPRAJRHRHZCQQ-UHFFFAOYSA-N |
| Smiles | ClC(N=C3)=CC=C3C2C1CCC(C2)N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (±)-Epibatidine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 1.23 | 5 | |
| ethanol | 24.55 | 100 |
制备储备液 for (±)-Epibatidine
以下数据基于产品分子量 208.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.79 mL | 23.96 mL | 47.92 mL |
| 5 mM | 0.96 mL | 4.79 mL | 9.58 mL |
| 10 mM | 0.48 mL | 2.4 mL | 4.79 mL |
| 50 mM | 0.1 mL | 0.48 mL | 0.96 mL |
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产品说明书 for (±)-Epibatidine
参考文献 for (±)-Epibatidine
参考文献是支持产品生物活性的出版物。
Badio and Daly (1994) Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 45 563 PMID: 8183234
Gerzarich et al (1995) Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 48 774 PMID: 7476906
Marks et al (1998) Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 285 377 PMID: 9536034
Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 20 2783 PMID: 10751429
Spande et al (1992) Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc. 114 3475
If you know of a relevant reference for (±)-Epibatidine, please let us know.
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关键词: (±)-Epibatidine, (±)-Epibatidine supplier, potent, nicotinic, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, nAChR, (Non-selective), 0684, Tocris Bioscience
3 篇 (±)-Epibatidine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (±)-Epibatidine 的部分引用包括：
Noviello et al (2021) Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell 184 2121 PMID: 33735609
Beckel et al (2006) Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. J Neurosci 290 F103 PMID: 16144967
Williams et al (2007) The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens. Br J Pharmacol 150 906 PMID: 17325648
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.