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说明： Partial NMDA agonist, acts glycine site
化学名： (RS)-3-Amino-1-hydroxypyrrolidin-2-one
生物活性 for (±)-HA-966
The overall effect of this much-investigated compound is the result of the actions of the two enantiomers: glycine-NMDA antagonism by the (+)-isomer and sedative and ataxic effects of the (-)-isomer. See separate isomers 0281 and 0282.
技术数据 for (±)-HA-966
| 分子量 | 116.12 |
| 储存 | Store at RT |
| CAS Number | 1003-51-6 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (±)-HA-966
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参考文献 for (±)-HA-966
参考文献是支持产品生物活性的出版物。
Evans et al (1978) Mg2+-like selective antagonism of excitatory amino acid - induced responses by α,ε-diaminopimelic acid, D-α-aminoadipate and HA-966 in isolated spinal cord of frog and immature rat. Brain Res. 148 536 PMID: 207392
Foster and Kem (1989) HA-966 antagonises NMDA receptors through a selective interaction with the glycine modulatory site. J.Neurosci. 9 2191 PMID: 2542488
Lodge (1989) Non-competitive NMDA antagonists. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 37
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关键词: (±)-HA-966, (±)-HA-966 supplier, NMDA, Receptors, 0198, Tocris Bioscience
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