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Discontinued Product
3272 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
说明： Mixed mGlu2 agonist/ mGlu3 antagonist
化学名： (1S,2S,4R,5R,6S)-rel-2-Amino-4-methylbicyclo[3.1.0]hexane-2,6-dicarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for (±)-LY 395756
(±)-LY 395756 is a selective metabotropic glutamate ligand for mGlu2 and mGlu3 receptors (Ki values are 0.165 μM and 0.302 μM respectively). Acts as an agonist at mGlu2 and antagonist at mGlu3. Analog of LY 354740 (Cat. No. 3246).
技术数据 for (±)-LY 395756
| 分子量 | 199.21 |
| 公式 | C9H13NO4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 852679-66-4 |
| PubChem ID | 11310142 |
| InChI Key | BQVZICWQBFTOJX-QNDZYWSYSA-N |
| Smiles | N[C@]1([C@](O)=O)[C@@]2([H])[C@@]([C@@H]2[C@](O)=O)([H])[C@H](C)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (±)-LY 395756
参考文献 for (±)-LY 395756
参考文献是支持产品生物活性的出版物。
Dominguez et al (2005) Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate receptors: identification of a subtype selective mGlu2 receptor agonist. J.Med.Chem. 48 3605 PMID: 15887967
关键词: (±)-LY 395756, (±)-LY 395756 supplier, LY395756, agonist, metabotropic, glutamate, ligand, receptor, receptors, mGlu2, mGlu3, Glutamate, (Metabotropic), Group, II, Receptors, 3272, Tocris Bioscience
2 篇 (±)-LY 395756 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (±)-LY 395756 的部分引用包括：
Wang et al (2013) Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons. Mol Pain 8 e61787 PMID: 23593498
Johnson (2017) Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and DA release in the dorsal striatum. Neuropharmacology 117 114 PMID: 28159646
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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