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Submit Review(±)-threo-3-Methylglutamic acid
说明： EAAT2 and EAAT4 blocker
纯度： ≥98% (HPLC)
生物活性 for (±)-threo-3-Methylglutamic acid
(±)-threo-3-Methylglutamic acid is a potent blocker of glutamate transport; selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively).
技术数据 for (±)-threo-3-Methylglutamic acid
| 分子量 | 161.16 |
| 公式 | C6H11NO4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 63088-04-0 |
| PubChem ID | 90479741 |
| InChI Key | GZKDJYLZHGMSFM-KSTNSCRMSA-N |
| Smiles | N[C@@]([C@@]([H])(C)CC(O)=O)([H])C(O)=O.[H][C@](CC(O)=O)(C)[C@@](N)([H])C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for (±)-threo-3-Methylglutamic acid
参考文献 for (±)-threo-3-Methylglutamic acid
参考文献是支持产品生物活性的出版物。
Eliasof et al (2001) Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J.Neurochem. 77 550 PMID: 11299317
Mitrovic et al (1998) Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. J.Biol.Chem. 273 14698 PMID: 9614067
Vandenberg et al (1997) Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol.Pharmacol. 51 809 PMID: 9145919
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关键词: (±)-threo-3-Methylglutamic acid, (±)-threo-3-Methylglutamic acid supplier, EAAT2, EAAT4, blockers, Excitatory, Amino, Acid, Transporters, GLT-1, Glutamate, Monoamine, Neurotransmitter, 0811, Tocris Bioscience
1 篇 (±)-threo-3-Methylglutamic acid 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (±)-threo-3-Methylglutamic acid 的部分引用包括：
Jarzylo and Man (2012) Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci 32 2552 PMID: 22396428
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.