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Discontinued Product
1953 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Negative allosteric modulator of mGlu5 receptors
化学名： [(3-Methoxyphenyl)methylene]hydrazone-3-methoxybenzaldehyde
纯度： ≥98% (HPLC)
生物活性 for DMeOB
Negative allosteric modulator of the metabotropic glutamate receptor mGlu5; displays reversible non-competitive inhibition of mGlu5-mediated responses (IC50 = 3 μM).
技术数据 for DMeOB
| 分子量 | 268.31 |
| 公式 | C16H16N2O2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 40252-74-2 |
| PubChem ID | 9604993 |
| InChI Key | CWHVUMNEZIBZFC-UHFFFAOYSA-N |
| Smiles | COC1=CC(=CC=C1)\N=C\N=C\C1=CC(OC)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DMeOB
参考文献 for DMeOB
参考文献是支持产品生物活性的出版物。
O'Brien et al (2003) A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5 Mol.Pharmacol. 64 731 PMID: 12920211
关键词: DMeOB, DMeOB supplier, Negative, allosteric, modulators, mGlu5, mGluR5, Group, I, Receptors, Glutamate, Metabotropic, nams, (Metabotropic), 1953, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.