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说明： Nrf2 pathway activator; neuroprotective
别名： Dimethyl fumarate
化学名： 2(E)-Butenedioic acid 1,4-dimethyl ester
纯度： ≥99%
生物活性 for DMF
DMF is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.
技术数据 for DMF
| 分子量 | 144.13 |
| 公式 | C6H8O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% |
| CAS Number | 624-49-7 |
| PubChem ID | 637568 |
| InChI Key | LDCRTTXIJACKKU-ONEGZZNKSA-N |
| Smiles | O=C(/C=C/C(OC)=O)OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DMF
参考文献 for DMF
参考文献是支持产品生物活性的出版物。
Scannevin et al (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 341 274 PMID: 22267202
Linker et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134 678 PMID: 21354971
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