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DMOG

Cat. No. 4408 3 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Prolyl hydroxylase inhibitor
化学名： N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
纯度： ≥97% (HPLC)
说明书
引用文献 (3)
评论 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DMOG

DMOG is a prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. Inhibits differentiation of hematopoietic stem cells (HSCs) in culture.

技术数据 for DMOG

分子量 175.14
公式 C6H9NO5
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 89464-63-1
PubChem ID 560326
InChI Key BNJOZDZCRHCODO-UHFFFAOYSA-N
Smiles O=C(C(OC)=O)NCC(OC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DMOG

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 17.51 100
DMSO 17.51 100

制备储备液 for DMOG

以下数据基于产品分子量 175.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 5.71 mL 28.55 mL 57.1 mL
5 mM 1.14 mL 5.71 mL 11.42 mL
10 mM 0.57 mL 2.85 mL 5.71 mL
50 mM 0.11 mL 0.57 mL 1.14 mL

Molarity Calculator

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产品说明书 for DMOG

分析证书/产品说明书
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化学品安全技术说明书

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关键词: DMOG, DMOG supplier, prolyl, 4-hydoxylase, P4H, inhibitors, inhibits, HIF, hypoxia-inducible, factors, 1a, 1alpha, 1α, proangiogenic, prolylhydroxylases, PHD, Hydroxylases, Hypoxia, Inducible, Factors, 4408, Tocris Bioscience

3 篇 DMOG 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DMOG 的部分引用包括：

Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329

Wiktoria et al (2022) Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production. Br J Cancer 127 1365-1377 PMID: 35840734

Izzie Jacques et al (2022) Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression. Sci Adv 8 eabo2295 PMID: 35867798

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DMOG 的评论

平均评分: 5 (基于 2 条评论。)

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DMOG.
By shubham dubey on 12/22/2021
分析类型： In Vitro
种属： Human
细胞系/组织： A549

IN cell culture to stabilize HIF1

review image
Good product.
By P Kumar on 05/27/2021
分析类型： In Vitro
种属： Human
细胞系/组织： A549

To check the HIF2a activity in A549 cells.

review image