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Submit ReviewDMP 543
说明： Potent, orally active ACh release enhancer
化学名： 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
纯度： ≥99% (HPLC)
生物活性 for DMP 543
DMP 543 is an acetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo. Also K+ channel blocker.
技术数据 for DMP 543
| 分子量 | 412.44 |
| 公式 | C26H18F2N2O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 160588-45-4 |
| PubChem ID | 9887884 |
| InChI Key | MUJBUUDUXGDXLW-UHFFFAOYSA-N |
| Smiles | FC1=CC(CC2(CC3=CC(F)=NC=C3)C3=CC=CC=C3C(=O)C3=C2C=CC=C3)=CC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DMP 543
参考文献 for DMP 543
参考文献是支持产品生物活性的出版物。
Zaczek et al (1998) Two new potent neurotransmitter release enhancers, 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-Bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 285 724 PMID: 9580619
Earl et al (1998) 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. J.Med.Chem. 41 4615 PMID: 9804701
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关键词: DMP 543, DMP 543 supplier, K+, channels, blockers, potent, ACh, release, enhancer, Potent, orally, active, Potassium, Channels, Non-Selective, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, DMP543, Other, Non-selective, Muscarinics, Voltage-Gated, 2330, Tocris Bioscience
1 篇 DMP 543 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DMP 543 的部分引用包括：
Ipavec et al (2011) KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res 64 397 PMID: 21740972
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.