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Submit ReviewDNQX disodium salt
说明： Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
化学名： 6,7-Dinitroquinoxaline-2,3-dione disodium salt
纯度： ≥98% (HPLC)
生物活性 for DNQX disodium salt
DNQX disodium salt is a more water-soluble form of DNQX (Cat. No. 0189). DNQX is a selective non-NMDA glutamate receptor antagonist. (IC50 = 0.1 μM and 0.5 μM for kainate and AMPA receptors, respectively). DNQX is a neuroleptic agent that shows pro-oxidative properties. DNQX selectively depolarizes rat thalamic reticular nucleus neurons.
技术数据 for DNQX disodium salt
| 分子量 | 296.1 |
| 公式 | C8H2N4O6Na2 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1312992-24-7 |
| PubChem ID | 45073428 |
| InChI Key | GPSBSOYURFUVKJ-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)[N+]([O-])=O)[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DNQX disodium salt
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 31.4 | 100 |
制备储备液 for DNQX disodium salt
以下数据基于产品分子量 296.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.38 mL | 16.89 mL | 33.77 mL |
| 5 mM | 0.68 mL | 3.38 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.38 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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产品说明书 for DNQX disodium salt
参考文献 for DNQX disodium salt
参考文献是支持产品生物活性的出版物。
Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701 PMID: 2899909
Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25 PMID: 2155495
Šarlauskas et al (2013) Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX) Acta Biochim.Pol. 60 227 PMID: 23757451
Lee et al (2010) Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J.Neurophysiol. 103 1728 PMID: 20107128
If you know of a relevant reference for DNQX disodium salt, please let us know.
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关键词: DNQX disodium salt, DNQX disodium salt supplier, Water-soluble, salt, Glutamate, Kainate, Receptors, iGluR, Ionotropic, AMPA, non-NMDA, neuroleptic, antagonists, 2312, Tocris Bioscience
8 篇 DNQX disodium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DNQX disodium salt 的部分引用包括：
Lindstrom et al (2010) Retinal input to efferent target amacrine cells in the avian retina. Proc Natl Acad Sci U S A 27 103 PMID: 20650017
Linnemann et al (2006) Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration. Vis Neurosci 7 59 PMID: 16872511
Pan et al (2016) Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice. J Neurosci 6 28137 PMID: 27319800
Tseng et al (2015) Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. Sci Rep 112 1214 PMID: 25552561
Abrahao et al (2017) Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus. Neuropsychopharmacology 42 1070 PMID: 27827370
Dilger et al (2015) Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci 35 3652 PMID: 25716863
Loo et al (2019) Single-cell transcriptomic analysis of mouse neocortical development. Nat Commun 10 134 PMID: 30635555
Li et al (2019) TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife 8 PMID: 31482844
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DNQX disodium salt 的评论
平均评分: 5 (基于 2 条评论。)
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Works as expected..
By
Anonymous on 06/01/2020
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Paraventricular nucleus of hypothalamus
DNQX (20 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.
Highly recommend.
By
Anonymous on 05/14/2019
分析类型： In Vivo
种属： Mouse
We delivered this drug intracranially in combination with AP5 to block glutamatergic transmission in the mouse VTA. Product was highly soluble and worked well and as described, producing a robust decrease in place preference behavior.
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