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Docosahexaenoic acid

Cat. No. 3687 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： RXR agonist
别名： DHA
化学名： (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid
纯度： ≥98%
说明书
引用文献 (3)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Docosahexaenoic acid

Docosahexaenoic acid is a endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.

技术数据 for Docosahexaenoic acid

分子量 328.49
公式 C22H32O2
储存 Store at -20°C
纯度 ≥98%
CAS Number 6217-54-5
PubChem ID 445580
InChI Key MBMBGCFOFBJSGT-KUBAVDMBSA-N
Smiles CC\C=C/C\C=C/C\C=C/C/C=C\C/C=C\C/C=C\CCC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Docosahexaenoic acid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.85 100
ethanol 32.85 100

制备储备液 for Docosahexaenoic acid

以下数据基于产品分子量 328.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.22 mL 30.44 mL
5 mM 0.61 mL 3.04 mL 6.09 mL
10 mM 0.3 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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产品说明书 for Docosahexaenoic acid

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Docosahexaenoic acid

参考文献是支持产品生物活性的出版物。

Mata de Urqunia et al (2000) Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 290 2140 PMID: 11118147

Zapata-Gonzalez et al (2008) Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids. J.Leukoc.Biol. 84 1172 PMID: 18632990

Hossain et al (2009) Mechanism of docosahexaenoic acid-induced inhibition of in vitro Aβ1-42 fibrillation and Aβ1-42-induced toxicity in SH-S5Y5 cells. J.Neurochem. 111 568 PMID: 19686246

If you know of a relevant reference for Docosahexaenoic acid, please let us know.

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关键词: Docosahexaenoic acid, Docosahexaenoic acid supplier, RXR, agonists, retinoid, X, receptors, selective, DHA, Retinoid, Receptor, 3687, Tocris Bioscience

3 篇 Docosahexaenoic acid 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Docosahexaenoic acid 的部分引用包括：

Wnuk et al (2018) Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Mol Neurobiol 55 5059 PMID: 28815487

Reyes-Reveles et al (2017) Phagocytosis-dependent ketogenesis in retinal pigment epithelium. J Biol Chem 292 8038 PMID: 28302729

Pal et al (2019) Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer. J Ovarian Res 12 49 PMID: 31128594

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Docosahexaenoic acid 的评论

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DHA.
By Anonymous on 01/31/2018
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Brain Slice

DHA used to verify if cells can metabolise various lipids. No effect seen here with DHA but we would need more controls to evaluate the product itself.

该领域的文献

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Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.