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Dooku 1

Cat. No. 6568 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity
化学名： 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Dooku 1

Dooku 1 reversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ~1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonizes Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.

技术数据 for Dooku 1

分子量 326.2
公式 C13H9Cl2N3OS
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 2253744-54-4
PubChem ID 137321150
InChI Key MNPOBXLPCWFONX-UHFFFAOYSA-N
Smiles ClC1=C(CSC2=NN=C(O2)C3=CC=CN3)C(Cl)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Dooku 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.62 100

制备储备液 for Dooku 1

以下数据基于产品分子量 326.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.33 mL 30.66 mL
5 mM 0.61 mL 3.07 mL 6.13 mL
10 mM 0.31 mL 1.53 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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产品说明书 for Dooku 1

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Dooku 1

参考文献是支持产品生物活性的出版物。

Evans et al (2018) Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br.J.Pharmacol. 175 1744 PMID: 29498036

If you know of a relevant reference for Dooku 1, please let us know.

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关键词: Dooku 1, Dooku 1 supplier, Dooku1, Dooku_1, Reversibly, blocks, Yoda1, activity, inhibits, inhibitors, Piezo1, channel, Piezo, Channels, 6568, Tocris Bioscience

1 篇 Dooku 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Dooku 1 的部分引用包括：

Yan et al (2022) Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone. Cell Biosci 12 191 PMID: 36457052

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