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说明： Selective δ agonist
别名： [D-Pen2,5]Enkephalin,[D-Pen2,D-Pen5]Enkephalin
纯度： ≥95% (HPLC)
生物活性 for DPDPE
DPDPE is a prototypical selective δ-opioid receptor agonist peptide. Inhibits electrically stimulated contraction of mouse vas deferens in vitro (EC50 = 5.2 nM), and is antinociceptive in vivo.
技术数据 for DPDPE
| 分子量 | 645.79 |
| 公式 | C30H39N5O7S2 |
| 序列 |
YXGFX (Modifications: X = D-Pen, Disulfide bridge: 2-5) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 88373-73-3 |
| PubChem ID | 14679813 |
| InChI Key | MCMMCRYPQBNCPH-NEUULRRLSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H](C(O)=O)C(C)(C)SSC1(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DPDPE
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for DPDPE
参考文献 for DPDPE
参考文献是支持产品生物活性的出版物。
Chandrakumar et al (1992) Analogs of the δ opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions. J.Med.Chem. 35 2928 PMID: 1323677
Clark et al (1986) [D-Pen2,D-Pen5]enkephalin (DPDPE): a δ-selective enkephalin with low affinity for μ1 opiate binding sites. Eur.J.Pharmacol. 128 303 PMID: 3025000
Fraser et al (2000) Supraspinal antinociceptive response to [D-Pen2,5]-enkephalin (DPDPE) is pharmacologically distince from that to other δ-agonists in the rat. J.Pharmacol.Exp.Ther. 295 1135 PMID: 11082450
If you know of a relevant reference for DPDPE, please let us know.
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关键词: DPDPE, DPDPE supplier, Selective, agonists, δ-opioid, delta-opioid, d-opioid, DOP, Receptors, OP1, delta-receptor, [D-Pen2,5]Enkephalin, [D-Pen2,D-Pen5]Enkephalin, Delta, Opioid, 1431, Tocris Bioscience
12 篇 DPDPE 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DPDPE 的部分引用包括：
Morse et al (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol 14 17 PMID: 23497702
Saloman et al (2011) Activation of peripheral δ-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats. Am J Physiol Heart Circ Physiol 190 379 PMID: 21664434
Leal et al (2013) Peripheral δ-opioid receptors attenuate the exercise pressor reflex. PLoS One 305 H1246 PMID: 23934854
Niu et al (2011) Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition. Neuroscience 180 344 PMID: 21296645
Morse et al (2011) Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target. PLoS One 6 e25643 PMID: 22003401
Tsitoura et al (2015) Inhibition of Anopheles gambiae odorant receptor function by mosquito repellents. J Biol Chem 290 7961 PMID: 25657000
Leroy et al (2019) Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron 102 260 PMID: 30946821
Nasrallah et al (2019) Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2. Cell Rep 27 86 PMID: 30943417
Dunning et al (2016) Multisite tyrosine phosphorylation of the N-terminus of Mint1/X11α by Src kinase regulates the trafficking of amyloid precursor protein. J Neurochem 137 518 PMID: 26865271
Marti et al (2013) Acute and chronic antiparkinsonian effects of the novel nociceptin/orphanin FQ receptor antagonist NiK-21273 in comparison with SB-612111. Br J Pharmacol 168 863 PMID: 22994368
Largent-Milnes et al (2013) Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. J Pharmacol Exp Ther 347 7 PMID: 23860305
Peart et al (2007) Impaired p38 MAPK/HSP27 signaling underlies aging-related failure in opioid-mediated cardioprotection. J Mol Cell Cardiol 42 972 PMID: 17407780
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