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说明： Nitroindoline-caged GABA
化学名： 1-(4-Aminobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline
纯度： ≥98% (HPLC)
生物活性 for DPNI-caged-GABA
Nitroindoline-caged GABA (Cat.No. 0344) with similar photochemical properties to MNI-glutamate (Cat. No. 1490); for example, the same quantum yield (0.085). Highly water soluble; exhibits fast photorelease that is efficient at near-UV and 405 nm wavelengths.
许可信息
Sold under licence from the Medical Research Council.
技术数据 for DPNI-caged-GABA
| 分子量 | 499.3 |
| 公式 | C15H23N3O12P2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 927866-58-8 |
| PubChem ID | 15953814 |
| InChI Key | QLCHBTSDKGMLRN-UHFFFAOYSA-N |
| Smiles | O=C(CCCN)N2C1=C([N+]([O-])=O)C=CC(OC(COP(O)(O)=O)COP(O)(O)=O)=C1CC2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DPNI-caged-GABA
参考文献 for DPNI-caged-GABA
参考文献是支持产品生物活性的出版物。
Wieboldt et al (1994) Synthesis and photochemistry of photolabile derivatives of gamma-aminobutyric acid for chemical kinetic investigations of the gamma-aminobutyric acid receptor in the millisecond time region. Biochemistry 33 1526 PMID: 8312272
Trigo et al (2009) Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ. J.Neurosci.Meths. 181 159 PMID: 19422852
Trigo (2010) Presynaptic miniature GABAergic currents in developing interneurons. Neuron 66 235 PMID: 20435000
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2 篇 DPNI-caged-GABA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DPNI-caged-GABA 的部分引用包括：
Nunez-Parra et al (2013) Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination. PLoS One 110 14777 PMID: 23959889
Spoljaric et al (2019) KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice. Cell Rep 26 1073 PMID: 30699338
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