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DPTIP

Cat. No. 6903 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective N-SMase2 inhibitor; brain penetrant
化学名： 2,6-Dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DPTIP

DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.

技术数据 for DPTIP

分子量 378.45
公式 C21H18N2O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 351353-48-5
PubChem ID 1131802
InChI Key JMXVHYPSBANVAQ-UHFFFAOYSA-N
Smiles COC1=CC(C2=NC(C3=CC=CC=C3)=C(C4=CC=CS4)N2)=CC(OC)=C1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DPTIP

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.84 100

制备储备液 for DPTIP

以下数据基于产品分子量 378.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.42 mL
5 mM 0.53 mL 2.64 mL 5.28 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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参考文献 for DPTIP

参考文献是支持产品生物活性的出版物。

Rojas et al (2018) DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci.Rep. 8 17715 PMID: 30531925

If you know of a relevant reference for DPTIP, please let us know.

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关键词: DPTIP, DPTIP supplier, neutral, sphingomyelinase, 2, nSMase2, inhibition, inhibitors, inhibits, Sphingomyelin, phosphodiesterase, SMase, metabolically, stable, brain, penetrant, bbb, Other, Hydrolases, 6903, Tocris Bioscience

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