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Submit ReviewDSP-4
说明： Adrenergic neurotoxin
化学名： N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for DSP-4
DSP-4 is an adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.
技术数据 for DSP-4
| 分子量 | 313.06 |
| 公式 | C11H15BrClN.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 40616-75-9 |
| PubChem ID | 38533 |
| InChI Key | NDDRNRRNYOULND-UHFFFAOYSA-N |
| Smiles | BrC1=CC=CC=C1CN(CC)CCCl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for DSP-4
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 31.31 | 100 | |
| ethanol | 31.31 | 100 |
制备储备液 for DSP-4
以下数据基于产品分子量 313.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.19 mL | 15.97 mL | 31.94 mL |
| 5 mM | 0.64 mL | 3.19 mL | 6.39 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.19 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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产品说明书 for DSP-4
参考文献 for DSP-4
参考文献是支持产品生物活性的出版物。
Jaim-Etcheverry and Zieher (1980) DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 188 513 PMID: 7370771
Kawamura et al (2005) Short and long term analysis of heart rate variations in spontaneous hypertensive rats: effect of DSP-4 administration. Biomed.Pharmacother. 59 S203 PMID: 16275495
Haidkind et al (2002) Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N(2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces DA release potential in the nucleus accumbens shell in conscious rats. Neurosci.Letts. 332 79
If you know of a relevant reference for DSP-4, please let us know.
关键词: DSP-4, DSP-4 supplier, Adrenergic, neurotoxin, Compounds, Adrenoceptors, Receptors, noradrenergic, neurons, neurotoxins, Related, 2958, Tocris Bioscience
2 篇 DSP-4 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DSP-4 的部分引用包括：
Li et al (2015) Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain. Toxins (Basel) 7 2422 PMID: 26131771
Coura et al (2013) Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex. FASEB J 27 4343 PMID: 23882123
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