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DSRM-3716

Cat. No. 7414 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and reversible SARM1 NAD hydrolase inhibitor
化学名： 5-Iodoisoquinoline
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DSRM-3716

DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.

技术数据 for DSRM-3716

分子量 255.06
公式 C9H6IN
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 58142-99-7
PubChem ID 11391181
InChI Key CUILFTFMBBGSFT-UHFFFAOYSA-N
Smiles IC1=CC=CC=2C=NC=CC12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DSRM-3716

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 25.51 100
DMSO 25.51 100

制备储备液 for DSRM-3716

以下数据基于产品分子量 255.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.6 mL 39.21 mL
5 mM 0.78 mL 3.92 mL 7.84 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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产品说明书 for DSRM-3716

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for DSRM-3716

参考文献是支持产品生物活性的出版物。

O Hughes et al (2021) Small molecules SARM1 inhibitors recapitulate the SARM1-/- phenotype and allow recovery of a metastable pool of axons fated to degenerate. Cell Rep. 34 PMID: 33406435

If you know of a relevant reference for DSRM-3716, please let us know.

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关键词: DSRM-3716, DSRM-3716 supplier, SARM1, NAD, hydrolase, inhibitor, inhibits, inhibitors, axonal, degeneration, toll-like, receptor, signaling, ADPR, Other, Hydrolases, Toll-like, Receptors, 7414, Tocris Bioscience

1 篇 DSRM-3716 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DSRM-3716 的部分引用包括：

Melanie et al (2022) An improved organotypic cell culture system to study tissue-resident macrophages ex vivo. Cell Rep Methods 2 100260 PMID: 36046625

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