Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDTG
说明： High affinity ligand (σ1 = σ2)
化学名： 1,3-Di-(2-tolyl)guanidine
生物活性 for DTG
Displays high and roughly equal affinity for both σ1 and σ2 receptors.
技术数据 for DTG
| 分子量 | 239.32 |
| 公式 | C15H17N3 |
| 储存 | Store at RT |
| CAS Number | 97-39-2 |
| PubChem ID | 7333 |
| InChI Key | OPNUROKCUBTKLF-UHFFFAOYSA-N |
| Smiles | CC1=C(NC(=N)NC2=C(C)C=CC=C2)C=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DTG
参考文献 for DTG
参考文献是支持产品生物活性的出版物。
He et al (1993) Synthesis and binding characteristics of potential SPECT imaging agents for σ1 and σ2 binding sites. J.Med.Chem. 36 566 PMID: 8496936
Quirion et al (1992) A proposal for the classification of sigma binding sites. TiPS 13 85 PMID: 1315463
按标靶查看相关产品
按产品操作查看相关产品
关键词: DTG, DTG supplier, High, affinity, ligand, σ1, sigma1, σ2, sigma2, General, Receptors, Sigma-Related, 0841, Tocris Bioscience
2 篇 DTG 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DTG 的部分引用包括：
Hall et al (2009) Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. PLoS One 164 470 PMID: 19723565
Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Neuroscience 350 290 PMID: 24891452
DTG 的评论
平均评分: 5 (Based on 1 Review.)
Have you used DTG?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
DTG specifically protects sigma-1 and sigma-2 receptors binding sites..
By
Timur Mavlyutov on 01/06/2018
分析类型： In Vitro
种属： Rat
细胞系/组织： PC12
Photolabeling experiment by Iodoazidofenpropimorph labels multiple receptors, which can be later seen on auto radiogram. Sigma-1 (26kDa) and Sigma-2 (18kDa) receptors were also labeled. To be sure that these two bands are true Sigma-1 and Sigma-2 receptors, photolabeling experiment was performed in the presence of DTG (second lane). Both Sigma-1 and Sigma-2 receptors were selectively protected.
