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Submit ReviewDynarrestin
说明： Inhibitor of Hedgehog (Hh) signaling; inhibits cytoplasmic dynein
化学名： Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate
纯度： ≥98% (HPLC)
生物活性 for Dynarrestin
Dynarrestin is a dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.
技术数据 for Dynarrestin
| 分子量 | 431.5 |
| 公式 | C22H23F2N3O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2222768-84-3 |
| PubChem ID | 137919864 |
| InChI Key | UZNNDDDSGCMQOQ-UHFFFAOYSA-N |
| Smiles | CCOC(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(S1)NC3=C(C=C(C=C3)F)F)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Dynarrestin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 43.15 | 100 |
制备储备液 for Dynarrestin
以下数据基于产品分子量 431.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.59 mL | 23.17 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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产品说明书 for Dynarrestin
参考文献 for Dynarrestin
参考文献是支持产品生物活性的出版物。
Höing et al (2018) Dynarrestin, a novel inhibitor or cytoplasmic dynein. Cell Chem.Biol. 25 357 PMID: 29396292
If you know of a relevant reference for Dynarrestin, please let us know.
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关键词: Dynarrestin, Dynarrestin supplier, Dynarrestin, hedgehog, Hh, signaling, inhibitors, inhibits, dynein, cytoplasmic, Hedgehog, Signaling, 6526, Tocris Bioscience
3 篇 Dynarrestin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Dynarrestin 的部分引用包括：
Jian et al (2021) Mechanical Counterbalance of Kinesin and Dynein Motors in a Microtubular Network Regulates Cell Mechanics, 3D Architecture, and Mechanosensing. ACS Nano 15 17528-17548 PMID: 34677937
Charles E et al (2019) Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles. J Virol 93 PMID: 31375591
Sandra L et al (2023) Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix. iScience 26 105965 PMID: 36824274
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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