EB 1089

Name: EB 1089
Brand: Tocris Bioscience
SKU: 3993

Cat. No. 3993 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3993 has been discontinued.

View all Vitamin D Receptors products.

说明： Vitamin D receptor (VDR) agonist

别名： Seocalcitol

化学名： (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol

纯度： ≥98% (HPLC)

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for EB 1089

EB 1089 is a vitamin D receptor (VDR) agonist; analog of calcitriol (Cat. No. 2551). Exhibits anti-tumor and anti-proliferative activity with reduced hypercalcemic effects. 60 times more potent in inhibiting MCF-7 cell growth in vitro; also shown to induce autophagy in MCF-7 cells. Reverses the effects of parathyroid hormone-related protein (PTHrP).

技术数据 for EB 1089

分子量	454.68
公式	C₃₀H₄₆O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	134404-52-7
PubChem ID	5288149
InChI Key	LVLLALCJVJNGQQ-SEODYNFXSA-N
Smiles	C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](/C=C/C=C/C(CC)(O)CC)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for EB 1089

分析证书/产品说明书

化学品安全技术说明书

参考文献 for EB 1089

参考文献是支持产品生物活性的出版物。

Lu et al (2008) Vitamin D₃ analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57. Mol.Cancer Ther. 7 1268 PMID: 18483314

Bhatia et al (2009) EB1089 inhibits the parathyroid hormone-related protein-enhanced bone metastasis and xenograft growth of human prostate cancer cells. Mol.Cancer Ther. 8 1787 PMID: 19584236

Abdaimi et al (1999) Reversal of hypercalcaemia with the vitamin D analogue EB1089 in a human model of squamous cancer. Cancer Res, 59 3325

Ormerod et al (2008) The calci. analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. Exp.Lung.Rs. 34 155

Hoyer-Hansen et al (2005) Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ. 12 1297 PMID: 15905882

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关键词: EB 1089, EB 1089 supplier, EB1089, VDR, agonist, Vitamin, D, receptors, seocalcitol, VDR-like, Seocalcitol, Receptors, Autophagy, 3993, Tocris Bioscience