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Ebio1

Cat. No. 8137 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： KCNQ2 activator
化学名： N-(1,2-Dihydro-5-acenaphthylenyl)-4-fluorobenzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ebio1

Ebio1 is an activator of KCNQ2 voltage-gated potassium channels (EC50 = 247 nM). Ebio1 activates KCNQ2 by increasing both the open probability and the conductance of the channel. Ebio1 has no effect on the voltage sensitivity of KCNQ1, KCNQ3, KCNQ4 and KCNQ5.

技术数据 for Ebio1

分子量 291.33
公式 C19H14FNO
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 339287-36-4
PubChem ID 759702
InChI Key VROYHHCUXRMIQY-UHFFFAOYSA-N
Smiles O=C(C1=CC=C(C=C1)F)NC2=CC=C3C4=C(CC3)C=CC=C42

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ebio1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.13 100
ethanol 5.83 20

制备储备液 for Ebio1

以下数据基于产品分子量 291.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.16 mL 34.33 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Ebio1

参考文献是支持产品生物活性的出版物。

Zhang et al (2024) A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol. 20 847 PMID: 38167918

If you know of a relevant reference for Ebio1, please let us know.

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关键词: Ebio1, Ebio1 supplier, KCNQ, channel, Potassium, KV, 7.2, Channels, voltage-gated, Voltage-Gated, 8137, Tocris Bioscience

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