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EBPC

Cat. No. 0518 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0518 has been discontinued.

View all Aldose Reductase products.
说明： Aldose reductase inhibitor
化学名： Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for EBPC

Potent aldose reductase inhibitor. Improves the cytotoxicity of anticancer reagents such as cisplatin (Cat.No. 2251) and doxorubicin (Cat.No. 2252) in HeLa cervical carcinoma cells through an increase in ERK activity.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for EBPC

分子量 261.28
公式 C14H15NO4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 4450-98-0
PubChem ID 54677973
InChI Key IGYRPDIWSYGHMY-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C(O)C(=O)N(CC2=CC=CC=C2)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for EBPC

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for EBPC

参考文献是支持产品生物活性的出版物。

Kyoung et al (2002) Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anti-cancer Drugs 13 859 PMID: 12394272

Mylari et al (1991) A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate and its congeners. J.Med.Chem. 34 1011 PMID: 1900532

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关键词: EBPC, EBPC supplier, Aldose, reductase, inhibitors, inhibits, Reductases, Carbohydrate, Metabolism, Pfizer, Reductase, 0518, Tocris Bioscience

2 篇 EBPC 的引用文献

引用文献是使用了 Tocris 产品的出版物。 EBPC 的部分引用包括：

Seo et al (2014) Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs. Pharmacol Res Perspect 90 99 PMID: 24695626

Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98 PMID: 22654757

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