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说明： Glutathione peroxidase mimic; peroxynitrite scavenger
化学名： 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
纯度： ≥98% (HPLC)
生物活性 for Ebselen
Ebselen is a glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits ferroptosis. Also inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H+/K+-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B1. Antioxidant and anti-inflammatory. Selectively inhibits Gq protein signaling and enhances differentiation of brown adipocytes. Inhibits SARS-CoV-2 Mpro in vitro (IC50 = 0.67 μM in FRET assay)
技术数据 for Ebselen
| 分子量 | 274.18 |
| 公式 | C13H9NOSe |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 60940-34-3 |
| PubChem ID | 3194 |
| InChI Key | DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC=C1[Se]N2C3=CC=CC=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ebselen
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 27.42 | 100 |
制备储备液 for Ebselen
以下数据基于产品分子量 274.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.24 mL | 36.47 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.29 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
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产品说明书 for Ebselen
参考文献 for Ebselen
参考文献是支持产品生物活性的出版物。
Schewe (1995) Molecular actions of ebselen--an antiinflammatory antioxidant. Gen.Pharmacol. 26 1153 PMID: 7590103
Yang et al (2000) Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 21 2237 PMID: 11133813
Fujisawa and Kadoma (2005) Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound. Anticancer Res. 25 3989 PMID: 16309189
Kuschak et al (2019) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 177 1898 PMID: 31881095
Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443
Jin et al (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 582 289 PMID: 32272481
If you know of a relevant reference for Ebselen, please let us know.
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关键词: Ebselen, Ebselen supplier, Glutathione, peroxidase, mimic, peroxynitrite, scavenger, inhibts, inhibitors, inhibits, lipoxygenases, cyclooxygenases, nitric, oxide, synthases, protein, kinase, C, H+, K+, atpases, Antioxidant, anti-inflammatory, ferroptosis, Gq, proteins, signaling, adipoc, Antioxidants, Ferroptosis, Heterotrimeric, G-protein, GTPases, COVID-19, 3C, and, 3CL, Proteases, Coronavirus, 5245, Tocris Bioscience
2 篇 Ebselen 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ebselen 的部分引用包括：
Ginam et al (2021) β2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep 11 21477 PMID: 34728663
Kuschak et al (2019) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 177 1898 PMID: 31881095
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Ebselen 的评论
平均评分: 3 (Based on 1 Review.)
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Used as a Nucleoside Diphosphate Kinase inhibitor.
By
Anonymous on 09/30/2024
分析类型： Ex Vivo
种属： Rat
细胞系/组织： Primary hippocampal neurons
The drug was incubated acutely at 100 μM as a potential NDK inhibitor.