Edaravone

Name: Edaravone
Brand: Tocris Bioscience
SKU: 0786

Cat. No. 0786 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0786 has been discontinued.

View all Antioxidants products.

说明： Anti-ischemic and antioxidant

别名： MCI-186

化学名： 3-Methyl-1-phenyl-2-pyrazolin-5-one

纯度： ≥99% (HPLC)

说明书

引用文献 (3)

生物活性技术数据说明书参考文献

生物活性 for Edaravone

Edaravone is a radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.

技术数据 for Edaravone

分子量	174.2
公式	C₁₀H₁₀N₂O
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	89-25-8
PubChem ID	4021
InChI Key	QELUYTUMUWHWMC-UHFFFAOYSA-N
Smiles	CC1=NN(C(=O)C1)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Edaravone

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Edaravone

参考文献是支持产品生物活性的出版物。

Kawai et al (1997) Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 281 921 PMID: 9152402

Kawasaki et al (2007) Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 322 274 PMID: 17429058

Watanabe et al (1994) Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 268 1597 PMID: 8138971

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

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关键词: Edaravone, Edaravone supplier, Anti-ischemic, antioxidant, free, radical, scavenger, MCI186, MCI-186, Antioxidants, Autophagy, 0786, Tocris Bioscience