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Submit ReviewEfaroxan hydrochloride
Discontinued Product
0792 has been discontinued.
View all Adrenergic α<sub>2</sub> Receptors products.
说明： α2 antagonist and I1, I3 ligand
化学名： 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Efaroxan hydrochloride
Efaroxan hydrochloride is a potent, highly selective α2 adrenoceptor antagonist and imidazoline I1 receptor ligand (pKi values are 7.87, 7.42, 5.74, 7.28 and < 5 for α 2A, α2B, α2C, I1, and I2 receptors respectively). Promotes insulin secretion, at a site distinct from I1 or I2 (the putative I3 receptor) in vitro and in vivo.
技术数据 for Efaroxan hydrochloride
| 分子量 | 252.74 |
| 公式 | C13H16N2O.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 89197-00-2 |
| PubChem ID | 11957548 |
| InChI Key | DWOIUCRHVWIHAH-UHFFFAOYSA-N |
| Smiles | Cl.CCC1(CC2=CC=CC=C2O1)C1=NCCN1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Efaroxan hydrochloride
分析证书目前不在网上提供。
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参考文献 for Efaroxan hydrochloride
参考文献是支持产品生物活性的出版物。
Chapleo et al (1984) α-Adrenoceptor reagents 2. Effects of modification of the 1,4-benzodioxan ring system on α-adrenoceptor activity. J.Med.Chem. 27 570 PMID: 6143826
Eglen et al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381 PMID: 9786027
Mayer and Taberner (2002) Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse. Eur.J.Pharmacol. 454 95 PMID: 12409010
Olmos et al (1994) Imidazolines stimulate release of Ins from RIN-5AH cells independently from imidazoline I1 and I2 receptors. Eur.J.Pharmacol. 262 41 PMID: 7813577
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关键词: Efaroxan hydrochloride, Efaroxan hydrochloride supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, antagonists, I1, I3, ligand, Receptors, General, Imidazolines, Adrenergic, Alpha-2, 0792, Tocris Bioscience
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