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Discontinued Product
0971 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
说明： Highly selective group II mGlu antagonist
化学名： (2S)-α-Ethylglutamic acid
纯度： ≥95% (HPLC)
生物活性 for EGLU
Selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord; presumed group II mGlu receptor antagonist.
技术数据 for EGLU
| 分子量 | 175.18 |
| 公式 | C7H13NO4 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 170984-72-2 |
| PubChem ID | 5311079 |
| InChI Key | QFYBYZLHPIALCZ-ZETCQYMHSA-N |
| Smiles | N[C@](CCC(O)=O)(CC)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for EGLU
参考文献 for EGLU
参考文献是支持产品生物活性的出版物。
Jane et al (1996) Potent antagonists at L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate recpetors in neonatal rat spinal cord. Neuropharmacology 35 1029 PMID: 9121605
Thomas et al (1996) (S)-α-Ethylglutamic acid and (RS)-α-cyclopropyl-4-phosphonophenylglycine as antagonists of L-AP4- and (1S,3S)-ACPD-induced depression of monosynaptic excitation of neonatal rat motoneurones. Br.J.Pharmacol. 117 70P
关键词: EGLU, EGLU supplier, selective, group, II, mGlur, antagonist, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, (Metabotropic), 0971, Tocris Bioscience
6 篇 EGLU 的引用文献
引用文献是使用了 Tocris 产品的出版物。 EGLU 的部分引用包括：
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Liu et al (2013) Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings. J Neurophysiol 110 505 PMID: 23636718
Ster et al (2011) Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. J Neurosci 108 9993 PMID: 21628565
Smith and Otis (2005) Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit. Proc Natl Acad Sci U S A 102 14901 PMID: 16199519
Kaushal and Schlichter (2008) Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. Proc Natl Acad Sci U S A 28 2221 PMID: 18305255
Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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