Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewElacridar hydrochloride
说明： P-gp and BCRP inhibitor
别名： GF 120918
化学名： N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Elacridar hydrochloride
Elacridar hydrochloride is a P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) inhibitor. Elacridar hydrochloride blocks P-gp-mediated multidrug resistance (MDR) of the cytotoxic drugs doxorubicin (Cat. No. 2252) and vincristine (Cat. No. 1257) in CHRC5 cells. Orally active.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline.
技术数据 for Elacridar hydrochloride
| 分子量 | 600.1 |
| 公式 | C34H33N3O5.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 143851-98-3 |
| PubChem ID | 170320 |
| InChI Key | IQOJZZHRYSSFJM-UHFFFAOYSA-N |
| Smiles | O=C1C3=C(C(C(NC4=CC=C(CCN5CC(C=C(OC)C(OC)=C6)=C6CC5)C=C4)=O)=CC=C3)NC2=C1C=CC=C2OC.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Elacridar hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 12 | 20 |
制备储备液 for Elacridar hydrochloride
以下数据基于产品分子量 600.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 8.33 mL | 41.66 mL | 83.32 mL |
| 1 mM | 1.67 mL | 8.33 mL | 16.66 mL |
| 2 mM | 0.83 mL | 4.17 mL | 8.33 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.67 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Elacridar hydrochloride
参考文献 for Elacridar hydrochloride
参考文献是支持产品生物活性的出版物。
Hyafil et al (1993) In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res. 53 4595 PMID: 8402633
Myer et al (1999) The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line. Oncol Rep. 6 217 PMID: 9864431
Durmus et al (2012) Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. Mol.Pharm. 9 3236 PMID: 23020847
If you know of a relevant reference for Elacridar hydrochloride, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: Elacridar hydrochloride, Elacridar hydrochloride supplier, GF120918, P-glycoprotein, P-gp, inhibitors, inhibits, multidrug, resistance, MDR, BCRP, ABCG2, ABCB1, GF, 120918, Multidrug, Transporters, 4646, Tocris Bioscience
4 篇 Elacridar hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Elacridar hydrochloride 的部分引用包括：
Ramesh et al (2014) Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids. J Exp Med 211 89 PMID: 24395888
Terrance G et al (2019) Lower Tubulin Expression in Glioblastoma Stem Cells Attenuates Efficacy of Microtubule-Targeting Agents. ACS Pharmacol Transl Sci 2 402-413 PMID: 32259073
Lahmann et al (2015) Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents. PLoS One 10 e0134476 PMID: 26225433
Jablonski et al (2014) Inhibiting drug efflux transporters improves efficacy of ALS therapeutics. Ann Clin Transl Neurol 1 996 PMID: 25574474
您是否知道使用了 Tocris Elacridar hydrochloride 的优秀论文？ 请告知我们.
Elacridar hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Elacridar hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
1uM of elacridar is used to block the p glycoprotein.
By
Shashirekha Shamamandri Markandaiah on 10/29/2018
分析类型： In Vitro
种属： Mouse
细胞系/组织： Endothelial cell, Astrocytes
Elacridar is used as P glycoprotein transporter blocker to enhance drug penetration in iPsc derived endothelial cell co cultured with ALS astrocytes.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.