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Submit ReviewEllipticine
说明： Antitumor and intercalating agent; inhibits DNA topoisomerase II
化学名： 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
纯度： ≥97% (HPLC)
生物活性 for Ellipticine
Ellipticine is a naturally occurring plant alkaloid with antitumor activity. DNA intercalating agent; blocks DNA topoisomerase II activity. Prevents p53 phosphorylation in lung cancer cells.
技术数据 for Ellipticine
| 分子量 | 246.31 |
| 公式 | C17H14N2 |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 519-23-3 |
| PubChem ID | 3213 |
| InChI Key | CTSPAMFJBXKSOY-UHFFFAOYSA-N |
| Smiles | CC1=C4C(C=CN=C4)=C(C)C3=C1C2=C(N3)C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ellipticine
参考文献 for Ellipticine
参考文献是支持产品生物活性的出版物。
Ohashi et al (1995) Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn.J.Cancer Res. 86 819 PMID: 7591958
Tewey et al (1984) Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J.Biol.Chem. 259 9182 PMID: 6086625
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关键词: Ellipticine, Ellipticine supplier, apoptosis, inducers, DNA, topoisomerase, II, inhibits, inhibitors, p53, phosphorylation, antitumor, intercalating, agents, plant, alkaloid, protein, kinase, CK2, Topoisomerase, DNA,, RNA, and, Protein, Synthesis, 3357, Tocris Bioscience
2 篇 Ellipticine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ellipticine 的部分引用包括：
Kishikawa et al (2015) Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget 6 8339 PMID: 25826076
Hou et al (2016) IDA is a broad-spectrum enterovirus replication inhibitor that selectively targets the virus internal ribosomal entry site. J Gen Virol 97 1122 PMID: 26879094
Ellipticine 的评论
平均评分: 5 (Based on 1 Review.)
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Ellipticine quickly kills melanoma cells in vitro.
By
Anonymous on 02/14/2019
分析类型： In Vitro
种属： Human
Ellipticine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.