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EN67, phenol

Cat. No. 8003 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： UBE2D degrader building block
化学名： N-[[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl]-2-propenamide
纯度： ≥95% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for EN67, phenol

EN67, phenol is a UBE2D building block. It covalently binds with the allosteric C111 residue on E2 ubiquitin-conjugating enzymes UBE2D. It can be used in targeted protein degraders to degrade neo-substrate targets, including the target proteins BRD4 and androgen receptor, in a UBE2D-dependent manner.

Usage Guidelines for EN67, phenol

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for EN67, phenol

分子量 264.26
公式 C13H13FN2O3
储存 Store at -20°C
纯度 ≥95% (HPLC)
InChI Key RCYKZLWHDJZATC-UHFFFAOYSA-N
Smiles O=C(NCC1ON=C(C1)C2=CC(F)=C(O)C=C2)C=C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for EN67, phenol

参考文献是支持产品生物活性的出版物。

Forte et al (2023) Targeted Protein Degradation through E2 Recruitment. ACS Chem.Biol. 18 897 PMID: 36940189

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该领域的文献

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia