Endoxifen

Cat. No. 3705 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent antiestrogen; ERα ligand

化学名： (E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol

纯度： ≥98% (HPLC)

引用文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Endoxifen

Endoxifen is an estrogen receptor α (ERα) ligand; potent antiestrogen. Metabolite of tamoxifen (Cat. No. 0999). Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.

技术数据 for Endoxifen

分子量	373.49
公式	C₂₅H₂₇NO₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	110025-28-0
PubChem ID	130621
InChI Key	MHJBZVSGOZTKRH-IZHYLOQSSA-N
Smiles	CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=C(O)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Endoxifen

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	37.35	100

制备储备液 for Endoxifen

以下数据基于产品分子量 373.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.39 mL	26.77 mL
5 mM	0.54 mL	2.68 mL	5.35 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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产品说明书 for Endoxifen

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Endoxifen

参考文献是支持产品生物活性的出版物。

Lim et al (2006) Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J.Pharmacol.Exp.Ther. 318 503 PMID: 16690721

Wu et al (2009) The tamox. metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor a for degradation in breast cancer cells. Cancer Res. 69 1722 PMID: 19244106

Wu et al (2011) Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 13 R27 PMID: 21392396

If you know of a relevant reference for Endoxifen, please let us know.

按标靶查看相关产品

Estrogen and Related Receptors

关键词: Endoxifen, Endoxifen supplier, Endoxifen, tamoxifen, metabolite, antiestrogen, ERalpha, ligands, estrogen, receptors, alpha, ERα, ERa, Estrogen, and, Related, Receptors, 3705, Tocris Bioscience

1 篇 Endoxifen 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Endoxifen 的部分引用包括：

Maria et al (2020) Divergent Effects of Daidzein and its Metabolites on Estrogen-Induced Survival of Breast Cancer Cells. Cancers (Basel) 12 PMID: 31936631

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Pathways for Endoxifen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.