Endoxifen

Name: Endoxifen
Brand: Tocris Bioscience
SKU: 3705

Cat. No. 3705 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3705 has been discontinued.

View all Estrogen and Related Receptors products.

说明： Potent antiestrogen; ERα ligand

化学名： (E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for Endoxifen

Endoxifen is an estrogen receptor α (ERα) ligand; potent antiestrogen. Metabolite of tamoxifen (Cat. No. 0999). Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.

技术数据 for Endoxifen

分子量	373.49
公式	C₂₅H₂₇NO₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	110025-28-0
PubChem ID	130621
InChI Key	MHJBZVSGOZTKRH-IZHYLOQSSA-N
Smiles	CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=C(O)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Endoxifen

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Endoxifen

参考文献是支持产品生物活性的出版物。

Lim et al (2006) Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J.Pharmacol.Exp.Ther. 318 503 PMID: 16690721

Wu et al (2009) The tamox. metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor a for degradation in breast cancer cells. Cancer Res. 69 1722 PMID: 19244106

Wu et al (2011) Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 13 R27 PMID: 21392396

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Estrogen and Related Receptors

关键词: Endoxifen, Endoxifen supplier, Endoxifen, tamoxifen, metabolite, antiestrogen, ERalpha, ligands, estrogen, receptors, alpha, ERα, ERa, Estrogen, and, Related, Receptors, 3705, Tocris Bioscience

1 篇 Endoxifen 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Endoxifen 的部分引用包括：

Maria et al (2020) Divergent Effects of Daidzein and its Metabolites on Estrogen-Induced Survival of Breast Cancer Cells. Cancers (Basel) 12 PMID: 31936631

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Pathways for Endoxifen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.