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Eplerenone

Cat. No. 2397 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective mineralocorticoid receptor antagonist
别名： Inspra,Epoxymexrenone
化学名： (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Eplerenone

Eplerenone is a selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.

技术数据 for Eplerenone

分子量 414.5
公式 C24H30O6
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 107724-20-9
PubChem ID 443872
InChI Key JUKPWJGBANNWMW-VWBFHTRKSA-N
Smiles O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Eplerenone

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.14 10

制备储备液 for Eplerenone

以下数据基于产品分子量 414.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 24.13 mL 120.63 mL 241.25 mL
0.5 mM 4.83 mL 24.13 mL 48.25 mL
1 mM 2.41 mL 12.06 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL

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产品说明书 for Eplerenone

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Eplerenone

参考文献是支持产品生物活性的出版物。

De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650 PMID: 2949071

McMahon and Cunningham (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190 PMID: 11714095

If you know of a relevant reference for Eplerenone, please let us know.

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关键词: Eplerenone, Eplerenone supplier, Selective, mineralocorticoid, receptor, antagonists, Aldosterone, Receptors, Inspra, Epoxymexrenone, Mineralocorticoid, Receptor, 2397, Tocris Bioscience

2 篇 Eplerenone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Eplerenone 的部分引用包括：

Urbanet et al (2010) Analysis of Ins sensitivity in adipose tissue of patients with primary aldosteronism. Purinergic Signal 95 4037 PMID: 20484481

Ibrahim et al (2018) Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and DEX Analgesia in an Animal Model of Low Back Pain. Front Cell Neurosci 12 453 PMID: 30524245

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